Endocrine Abstracts

Background: Parathyroid carcinoma (PC) is a rare cause of primary hyperparathyroidism (PHPT) and extremely rare endocrine malignancy during pregnancy. Different maternal and fetal/neonatal complications of PHPT occur in 67 and 80% of untreated cases respectively, probably more due to severe hypercalcemia.The diagnostic and therapeutic approaches are limited in pregnant women and require individual risk-benefit assessment.Aim: We present a case of PC mani...

Background: Immune checkpoint Inhibitors (ICIs) have revolutionized the treatment of vast array of cancers. Despite their efficacy, ICIs can cause various side effects related to the mechanism of action. Immune-related endocrine events (irEEs) are one of the most common immune-related adverse events (irAEs), accounting for 8.1% of all cases. We report two patients with durable responses to ICIs and concurrent serious irEEs.Case 1: A 58-year-old woman wit...

Background: Epidemiological data on AVP-deficiency is scarce, with non-univocal reported prevalence of 4 per 100.000 for all cases of central and nephrogenic DI without clear gender predominance. Disease registries are major tools for the assessment of epidemiological data, as well as real-life clinical practice, which could be quite valuable for AVP-d.Aim.: To assess the epidemiological data on ADH-D in Russian Registry for Central Diabetes Insipidus (R...